1.5 mL vials are an essential component in liquid chromatography (LC) analysis, especially for high performance liquid chromatography (HPLC) and mass spectrometry (MS). These vials are used as sample containers to ensure minimal contamination and optimal performance during analysis. This article explores the specifications, types, benefits, and applications of1.5 mL vials in LC analysis.

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1.5 mL Vial Types

Material Composition:

Borosilicate Glass: Most commonly used due to its chemical resistance and low thermal expansion. Available in clear or amber glass to protect light-sensitive samples.

Plastic Options: In cases where glass contamination is a concern, high-quality plastics can be used to minimize inorganic ion levels.

Vial Designs:

Short Thread Vials: These vials are designed with short thread caps for easy closure, providing a secure seal while allowing quick access to samples.

Crimp Top Vials: Provide a better seal and are ideal for volatile samples that need to minimize contact with air.

Conical bottom vials: Designed for limited volume sampling to facilitate complete sample recovery.

Seal options:

Pre-screw caps: Typically made of polypropylene with a silicone/PTFE liner to ensure a secure seal while providing easy access.

Crimp Caps: Provide a more robust closure that is less prone to leaking, especially under varying pressure conditions.

Key specifications

Volume: Typically 1.5 mL, available volume varies based on vial design.

Dimensions: Standard dimensions are approximately 32 x 11.6 mm, compatible with most autosamplers.

Residual volume: Designed to minimize residual volume to ensure maximum sample recovery.

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Advantages of using 1.5 mL vials

Low background contamination: Vials undergo a proprietary cleaning process that significantly reduces background particulate matter, which is critical for sensitive analyses such as LC/MS. This is particularly important because high particle counts can interfere with chromatographic separations.

Compatibility with Autosamplers: Designed to fit most HPLC and GC autosamplers, ensuring seamless integration into laboratory workflows. This compatibility improves efficiency in sample handling and analysis.

Quality Control and Authentication: Many manufacturers offer authentication for their vials, ensuring they meet the stringent quality standards necessary for reproducible analytical results.

Application Versatility: Due to its ability to handle a variety of sample types without causing contamination, it is suitable for a wide range of applications such as environmental testing, food safety analysis, and pharmaceutical research.

Applications in Liquid Chromatography

Pharmaceutical Analysis: Widely used in the pharmaceutical industry for analysis of active ingredients and impurities due to its reliability and low risk of contamination.

Environmental Testing: Ideal for collecting and analyzing water samples where low levels of contaminants are critical for accurate results.

Food Safety Testing: Used to detect additives, contaminants, and nutrients in food to ensure compliance with health regulations.

Research Applications: Commonly used in academic and industrial research environments where compound identification and quantification with high sensitivity and specificity is required.

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Conclusion

In summary, 1.5 mL vials play a vital role in the field of liquid chromatography, providing a reliable method of sample storage while minimizing the risk of contamination. Their diverse designs meet a variety of analytical needs across multiple industries, making them an indispensable tool in the modern laboratory. Continuous advancements in vial technology continue to improve their performance, ensuring they meet the ever-changing needs of analytical chemistry.

2 mL Autosampler Vials for Gas Chromatography

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